SS-31 – 10mg

Amino Sequence: Four-amino-acid peptide: D-Arg, Dmt, Lys, Phe (C-terminal amide)
Molecular Formula: C₃₂H₄₉N₉O₅ (free base)
Molecular Weight: 639.80 Daltons
PubChem CID: 11764719
CAS Number: 736992-21-5 (free base)
InChIKey: SFVLTCAESLKEHH-WKAQUBQDSA-N
Formal Charge: +3 at physiological pH

SS-31 is a synthetic tetrapeptide with a precisely defined four-amino-acid sequence built on an alternating cationic-aromatic motif: D-arginine (D-Arg), 2′,6′-dimethyltyrosine (Dmt), lysine (Lys), and phenylalanine (Phe).

The full sequence is D-Arg-Dmt-Lys-Phe-NH₂, a compact peptide carrying a C-terminal amide. This aromatic-cationic tetrapeptide belongs to the Szeto-Schiller peptide series, developed to reach the inner mitochondrial membrane without receptor mediation.

Its alternating aromatic and cationic residues permit energy-independent membrane permeation and significant accumulation at the inner mitochondrial membrane. Its molecular weight of 639.80 Daltons places SS-31 within the small-peptide range for experimental systems.

SS-31 Peptide: Mitochondrial Support Research

The core research focus of SS-31 is its interaction with mitochondria, particularly its ability to bind with cardiolipin.

Cardiolipin is a phospholipid found almost exclusively within the inner mitochondrial membrane. The alternating positively charged and aromatic structure of SS-31 allows it to cross cellular membranes without relying on a receptor and concentrate at the inner mitochondrial membrane. Once there, it associates with cardiolipin and may help stabilize the membrane’s structure under experimental conditions.

In laboratory studies, this stabilization has been investigated in relation to respiratory-chain supercomplexes, cytochrome-c peroxidase activity, mitochondrial reactive oxygen species, ATP production, and membrane potential. SS-31 is consequently studied as a mitochondrial-protective research peptide. Its proposed activity is structural rather than based on conventional receptor-mediated signaling.

Why Buy from Agape Peptides

Reproducible research starts with reliable material. Every compound we supply is produced under controlled synthesis conditions and verified before reaching your laboratory, because variations between lots may introduce variables that were not part of the original experimental design.

Each batch is tested for purity and molecular identity. A batch-specific Certificate of Analysis may be supplied with each order, documenting available purity results, identity confirmation, and net peptide content.

Traceable identity and purity: We verify molecular identity and screen for contaminants that could influence experimental results. When a compound is available in multiple salt forms or under different registry numbers, the supplied documentation identifies the applicable material.

Consistent handling and fulfilment: Products are supplied with packaging appropriate to their format, together with available handling and storage guidance designed to help preserve product integrity.

Standardization across research protocols: Consistent specifications and testing documentation help research teams compare results across studies and maintain protocol reproducibility.

Support for research professionals: Our team can provide available analytical documentation, clarify product specifications, and answer general questions about the materials supplied. We do not provide dosing recommendations, protocol-design assistance, or instructions for human or animal use.

Research Use Only: All compounds are supplied strictly for laboratory research and analytical purposes. They are not intended for human or veterinary use, diagnostic use, or therapeutic applications.